The epidemiology of notifiable diseases in Australia and the impact of the COVID-19 pandemic, 2012–2022

Background Infectious disease surveillance tracks disease epidemiology and informs prevention and control. Public health measures implemented in Australia during the COVID-19 pandemic (2020 to 2022) affected infectious disease epidemiology. We examined notifiable disease epidemiology in Australia from 2012 to 2022, evaluating disease trends and pandemic impacts. Methods We analysed case notifications supplied to the Australian National Notifiable Disease Surveillance System (NNDSS) from 1 January 2012 to 31 December 2022. The annual incidence and notification incidence trends were calculated and the average changes in annual incidence were investigated by Poisson regression. Results Over the study period, there were 14,087,045 notifications of 68 diseases. Respiratory diseases were the most commonly notified disease group (83% of all notifications) and vector-borne diseases the least (< 1%). The ten highest-incidence diseases comprised 97% of all notifications over the study period, with COVID-19 alone accounting for 72%. Notifications were most common among the 20–39-year age group (37%). From 2012–2019, notification incidence of gastrointestinal, respiratory and sexually transmissible infections increased, whereas for bloodborne viral hepatitis, vector-borne diseases and imported diseases it decreased. From 2020–2021, average notification incidence of most non-COVID-19 respiratory diseases decreased compared to the 2012–2019 period; sexually transmissible infections notification incidence remained fairly stable; notification incidence of some gastrointestinal diseases increased while others decreased; and notification of imported diseases markedly decreased. A rebound in notification incidence was seen for most diseases in 2022. Conclusions Prior to the COVID-19 pandemic, most notifiable diseases had increasing notification incidence, except for bloodborne viral hepatitis, vector-borne diseases and imported diseases. COVID-19-related public health measures had variable impacts on notifiable diseases.


Background
Infectious disease surveillance systems enable detailed analysis and interpretation of epidemiological data to inform public health policy and minimise morbidity and mortality [1].In Australia, notification of selected infectious diseases is required by public health legislation across all states and territories [2].Each jurisdiction defines its own notification list and receives data from doctors and/or laboratories.Jurisdictions then forward de-identified notification data for diseases on the National Notifiable Disease List (NNDL) (Additional file 1: Table S1) to the National Notifiable Disease Surveillance System (NNDSS), a passive surveillance system operational since 1991.
Since early 2020, the coronavirus disease-2019 (COVID-19) pandemic has caused social and economic disruption in Australia and globally [3,4].The non-pharmaceutical public health measures subsequently introduced to prevent and control COVID-19 (such as border closures, jurisdictional lockdowns, and mandatory maskwearing) have affected infectious disease transmission dynamics, along with healthcare-seeking behaviour, healthcare access, and testing strategies, all of which may impact disease notification rates [5][6][7].
Studies from other countries have highlighted changes in infectious disease notification trends in the setting of the COVID-19 pandemic.In China, respiratory and gastrointestinal disease notifications declined significantly in 2020 and non-respiratory disease notifications rebounded when public health control measures were relaxed at the end of 2020 [8].Countries in Europe reported similar decreases in respiratory, gastrointestinal, and vector-borne disease notifications in 2020 [9,10], with notifications rebounding when public health control measures were lifted.In Taiwan, while notifications for most respiratory and imported infectious diseases declined in 2020, the overall incidence of sexually transmissible infections increased [11].
Limited data from Australia from early in the pandemic and for limited jurisdictions [6,12] also suggest that the COVID-19 pandemic and related public health control measures impacted notifiable disease trends.However, an assessment of the differential impacts of COVID-19-related control measures on a range of disease notifications is currently lacking.
A previous analysis of the first 21 years of NNDSS data (1991-2011) [1] provided a comprehensive overview of the historical epidemiology of notifiable diseases in Australia, describing disease trends over time.Here, we aim to conduct a detailed analysis of NNDSS data from 2012 to 2022 to examine notifiable disease trends over the last decade, including the impacts of the COVID-19 pandemic.

Methods
We analysed case notifications of nationally notified diseases to the NNDSS from 1 January 2012 to 31 December 2022 according to their diagnosis date.We excluded human immunodeficiency virus (HIV) and Creutzfeldt-Jacob disease (CJD) as they are monitored under different national surveillance systems.Case definitions for all notifiable diseases are developed by the Communicable Disease Network of Australia (CDNA) and have been in use since 2004, and undergo subsequent periodic revisions and updates [13].The year that a disease became notifiable is listed as 1991 for those that were nationally notifiable when NNDSS began in 1991 [14] (Additional file 1: Table S1); however, diseases introduced after 1991 might have cases notified to NNDSS prior to becoming nationally notifiable.Some diseases became nationally notifiable during the study period and some diseases are not notifiable in all jurisdictions or have become notifiable in different jurisdictions at different times.We categorised each notifiable disease into one of six groups based on the main mode of transmission/acquisition: gastrointestinal, respiratory, vector-borne diseases, bloodborne viral hepatitis, sexually transmissible infections, and others.We also created an additional group of primarily imported diseases to enable analysis of travelrelated infections; there is an overlap of individual diseases in this group with other disease groups (Additional file 1: Table S1).We divided the study period into two sub-periods (2012-2019, 2020-2022) to enable analysis of the impact of the COVID-19 pandemic and associated public health prevention measures on notifications.
We report the number and annual incidence of notified cases nationally and by jurisdiction.For all-cause, disease-group, and disease-specific incidence calculations, all notified cases were included and Australian Bureau of Statistics (ABS) resident population estimates on 30 June for each study year were used [15].For individual diseases, incidence calculations were confined to years the disease was notifiable, either nationally or in a jurisdiction.Misclassified notification data were excluded from analyses.Formal ABS national, jurisdictional, and age-based population estimates were not available for June 30, 2022; national and jurisdictional populations were instead estimated based on available 2022 data till 31 March and projected data from the ABS population clock for 30 September 2022 [15].Age was divided into five groups: < 5 years, 5-19 years, 20-39 years, 40-59 years, and ≥ 60 years.Age-specific population estimates from 31 March 2022 were used for age-based incidence calculations, due to there being no age-based data available for 30 September 2022 [15].
Average changes in annual notification incidence over the study period were investigated by Poisson regression for diseases with ≥ 400 notifications.This was done for disease groups and individual diseases, as well as by jurisdictions and age groups.Results were considered statistically significant if p < 0.05.
The notification incidence trend was calculated for six disease groups, excluding respiratory diseases.The number of notifications averted during the pandemic was estimated by assuming the counterfactual was represented by an extension of the pre-pandemic trend and subtracting the observed from the expected number of notifications.Influenza notifications contributed substantially to respiratory disease notifications prior to 2020; due to significant year-to-year variation in influenza notifications, a pre-pandemic trend could not be established with confidence.Therefore, an estimation of the number of respiratory notifications averted due to the COVID-

Results
The NNDSS recorded 14,087,045 notifications of 68 diseases from 1 January 2012 to 31 December 2022 (Table 1).Respiratory diseases were the most commonly notified disease group, comprising 83% of all notifications over the study period; vector-borne diseases were the least common (< 1%; Table 1).Notification numbers without inclusion of COVID-19 are presented in Additional file 1: Table S2.COVID-19, notifiable from 2020, was the most commonly notified disease overall (10,124,662 notifications [72.0%]) and comprised the majority of notifications in 2022 (9,557,691 [94%]; Table 2).The ten highest-incidence diseases over the study period were COVID-19, influenza, chlamydia, respiratory syncytial virus (RSV), campylobacteriosis, gonorrhoea, varicella zoster virus (VZV; shingles and unspecified combined), salmonellosis, pertussis, and hepatitis C, collectively comprising 97% of all notifications (Table 2).Fewer than twenty notifications were received for seven diseases, and no notifications were received for eleven diseases (Table 2).

Trends from 2012 to 2019
From 2012 to 2019, the notification incidence of gastrointestinal, respiratory, sexually transmissible infections, and 'other' diseases increased, whereas the notification incidence of bloodborne viral hepatitis, vector-borne diseases, and imported diseases decreased (Fig. 3, Table 2).Notification incidence of respiratory diseases increased by an average of 23% per year, with influenza an important driver due to two particularly high-incidence years (2017 and 2019) and an average annual increase in incidence of 30% per year from 2012 to 2019 (Table 2).Notable increases in average annual incidence were also demonstrated for invasive pneumococcal (3% per year) and meningococcal disease (5% per year), whereas pertussis, measles, and legionellosis declined in incidence by 8%, 5%, and 2% per year, respectively.Most gastrointestinal diseases also increased in notification incidence, particularly Shiga-toxin-producing E. coli, shigellosis, campylobacteriosis, and hepatitis A which rose by 30%, 28%, 12%, and 8% per year, respectively (Table 2).In contrast, notification incidence of cryptosporidiosis and listeriosis declined (1% and 6% per year, respectively).Notification incidence for all vector-borne diseases decreased during this time period, with Barmah Forest virus (BFV) declining the most (33% per year).Imported vector-borne diseases, such as dengue and chikungunya also demonstrated a decrease in annual incidence (6% and 2% per year, respectively), whereas malaria remained stable (Table 2).All sexually transmissible infections increased in notification incidence at an    NB: overlap of individual diseases within the 'imported' disease group with other disease groups Abbreviations: N/A Data not available as the disease is not notifiable in that year, 95% CI 95% confidence interval, nec not otherwise specified average increase of 5% per year, with incidence peaking in 2019 (Fig. 3, Table 2).Syphilis demonstrated the largest increase of 15% per year.A 3% per year decrease in average annual notification incidence of bloodborne viral hepatitis from 2012 to 2019 was noted, with the incidence of hepatitis B and hepatitis C infections declining at an average of 4% and 2% per year, respectively.Other diseases that increased in incidence during 2012-2019 included VZV (shingles/unspecified; average increase of 23% per year) and leptospirosis (average increase of 5% per year; Table 2).

Trends from 2020 to 2022
During the first 2 years of the COVID-19 pandemic (2020-2021), mean notification incidence of most non-COVID-19 respiratory diseases decreased compared to the 2012-2019 period; for example, influenza decreased from 487/100,000/year in 2012-2019 to 43/100,000/year in 2020-2021 (Table 2).A rebound was observed for most diseases in 2022, including influenza, invasive pneumococcal disease, and diphtheria (Fig. 3, Table 2).Exceptions to this pattern were legionellosis and ornithosis for which increased notifications were observed in 2020-2022 (Fig. 3, Table 2).Varying trends in incidence were seen for gastrointestinal infections compared to previous years: campylobacteriosis and Shiga-toxin-producing E. coli increased, infections that are largely imported (typhoid, paratyphoid, hepatitis A, and hepatitis E) as well as rotavirus and shigellosis decreased in 2020-2021 and then rebounded in 2022.Some other non-imported gastrointestinal diseases (e.g.cryptosporidiosis and salmonellosis) decreased with no rebound in 2022 (Fig. 3, Table 2).Notification incidence of vector-borne diseases continued to decline in 2020 and 2021 (mean incidence 22/100,000/year compared to 32/100,000/year in 2012-2019) (Fig. 3, Table 2), with imported vector-borne diseases (dengue, chikungunya, malaria) demonstrating marked decreases (Fig. 3, Table 2) followed by an increase in incidence in 2022, although still at rates below those seen prior to 2020.While sexually transmissible infection notification incidence remained fairly stable throughout this period compared to 2012-2019, bloodborne viral hepatitis notification incidence decreased from 2020 to 2022.Other notable trends included a marked increase in leptospirosis and Q-fever notification incidence in 2021 compared to previous years and ongoing increases in VZV (shingles/unspecified) notification incidence throughout 2020-2021 (Fig. 3, Table 2).The notification incidence of Japanese encephalitis (JE) also increased markedly in 2022 (0.14/100,000/year) compared to previous years (Table 2).The observed pre-pandemic trends in notification incidence for individual disease groups from 2012 to 2019 and the subsequent predicted trends from 2020 to 2022 are shown in Fig. 4. A pre-pandemic trend for respiratory diseases was difficult to establish due to significant seasonal variation in influenza cases, which dominate pre-COVID respiratory notifications.While an estimation of the number of respiratory notifications averted was not done due to difficulties in establishing a pre-pandemic baseline, notably, influenza notifications decreased from an average of 119,450 notifications per year from 2012 to 2019 to 85,136 notifications per year from 2020 to 2022.Based on pre-pandemic trends, we estimate that 65,775 gastrointestinal disease notifications, 120,821 sexually transmissible infection notifications, 9119 bloodborne viral hepatitis notifications, 5289 imported disease notifications, 87 vector-borne disease notifications, and 17,964 'other' disease notifications were averted during the pandemic.

Discussion
We provide an overview of disease trends for all nationally notifiable diseases in Australia (except HIV and CJD) from 2012 to 2022, including the impacts of the COVID-19 pandemic and associated public health measures.Case notifications increased steadily from 2012 to 2019, with a sharp rise from 2020 due to a high number of COVID-19 notifications, particularly during the delta and omicron waves in late 2021 and 2022.Excluding COVID-19 Fig. 4 Observed notification incidence, pre-pandemic trend, and predicted trend for disease groups, Australia 2012-2022.Legend: Trends for respiratory diseases are difficult to establish due to significant seasonal variations in influenza notifications notifications, 3,962,383 notifications were received during the study period, a greater than 60% increase in notifications compared to the preceding 21-year period (1991 to 2011; 2,421,134 notifications) [1].Multiple factors have likely contributed to this increase, including the addition of eight diseases (e.g.RSV) to the NNDL, true changes in disease incidence, new diagnostic methods, increased uptake of testing in response to awareness, and screening campaigns (e.g. for sexually transmissible infections) and growth in international travel prior to the COVID-19 pandemic.
We found an average annual increase in the incidence of all notifiable diseases of 11% per year from 2012 to 2019.The onset of the COVID-19 pandemic in 2020 and subsequent public health measures including international border closures, jurisdictional lockdowns resulting in reduced movement within and between jurisdictions, capacity limits on public venues, work and study from home, and mandatory mask-wearing had a variable impact on notification rates across different disease groups.Notification rates also varied across jurisdictions for some disease groups; for example, in 2020, non-COVID-19 respiratory diseases did not decline in incidence as much in the NT as for other jurisdictions, potentially related to an absence of community transmission of SARS-CoV-2 in the NT and a consequent lower stringency of public health restrictions [16].Decreases in incidence were observed for imported diseases, most non-COVID-19 respiratory diseases and gastrointestinal diseases throughout 2020-2021, whereas increases in incidence were observed for diseases such as legionellosis, leptospirosis, and VZV (shingles/unspecified) where transmission is not likely to have been influenced by pandemic-related public health measures or in the case of VZV (shingles/unspecified), cases may have been triggered by COVID-19 infection.
Based on pre-pandemic trends, we estimated that COVID-19-related public health measures had a substantial impact on notifiable disease rates, resulting in a considerable number of averted notifications, in particular for sexually transmissible infections and gastrointestinal diseases.This assumption may not be valid for some diseases such as influenza which have significant seasonal variations [17].For all disease groups, the number of notifications in 2022 had not yet reached predicted levels and it will be interesting to monitor this trend over the next few years.Our study highlights some important epidemiological trends.Respiratory diseases were the most common notifiable disease group in all jurisdictions.COVID-19 and influenza were the most commonly notified diseases overall, accounting for 80% of all notifications.Influenza notification rates were particularly high in 2017 and 2019, aligning with reports of increased influenzarelated hospitalisations and deaths in these years [18] and reflecting global trends [19].Contributing factors include low vaccine effectiveness in 2017, an earlier start and longer season in 2019 [18] and increased testing in the community [20].
Similar to other countries [7][8][9][10][11], the notification incidence of most non-COVID respiratory diseases decreased markedly in 2020 due to the implementation of wide-ranging non-pharmaceutical public health measures that altered behaviour and reduced human interactions.Changes in healthcare utilisation and access due to travel restrictions, healthcare facility closures, increased uptake of telehealth, and fear of contracting COVID-19 may also have led to decreased testing and diagnosis [5,21,22].Following the relaxation of public health restrictions and reopening of Australia's borders in late 2021, an increase in notification incidence for most respiratory diseases was observed in 2022, including large increases in COVID-19, influenza and RSV notifications.Ongoing community public health messaging regarding testing for influenza-like illnesses and the use of multiplex polymerase chain reaction (PCR) testing for respiratory viruses likely contributed to this increase.
The notification incidence of sexually transmissible infections increased steadily from 2012 to 2019, in keeping with a global increase of 58% in sexually transmissible infection burden since 1990 [23].Sexually tranmissible infections were the second most commonly notified disease group overall and in the Northern Territory comprised almost 30% of notifications.Notably, we observed a marked increase in syphilis notifications in all jurisdictions (national increase of 9% per year from 2012 to 2022) which mirrors findings from other high-income settings such as the USA [24] and Western Europe [25].Factors explaining this rise likely include an increase in high-risk sexual behaviours [24,26] including less condom use in certain populations following the widespread roll-out of HIV pre-exposure prophylaxis (PREP) [27].Additionally, in Australia, where a multi-jurisdictional outbreak of syphilis has led to increasing notification rates, testing has increased due to campaigns such as 'Young, deadly, free' [28], and 'Don't fool around with syphilis' [29] and guidance for consistent routine screening of defined risk groups (e.g.antenatal testing in pregnant women) [30].Difficulties in contact tracing in certain populations due to high mobility and certain sexual behaviours (e.g.anonymous sex, attendance at sex-on-premises venues) likely also contributed.
Notably, sexually transmissible infection notification incidence did not decrease markedly in 2020-2021, with incidence remaining similar to the average incidence observed from 2012 to 2019.A large survey (n= 1828) of Victorian residents in 2020 demonstrated that sexual behaviours fluctuated according to restrictions, with more engagement in physically distanced activities (e.g.virtual dates) during lockdowns, and an increase in casual sex during periods of eased restrictions [31].
The marked decrease in bloodborne viral hepatitis notification incidence over the study period likely reflects the success of public health measures such as the implementation of the universal hepatitis B vaccine in the childhood national immunisation program in 2000 [32], increased accessibility and availability of direct-acting antiviral treatments which became government-funded in 2016, and needle syringe and opioid treatment programs [33].
Gastrointestinal diseases were the third most commonly reported disease group during the study period, with increases particularly observed for Shiga-toxinproducing E. coli, shigellosis, and campylobacteriosis between 2012 and 2019, despite the latter only becoming notifiable in NSW in 2017.This could in part be due to a shift to culture-independent diagnostic testing for bacterial enteric pathogens following the 2013 introduction of multiplex polymerase chain reaction (PCR) diagnostic assays in Australia and their subsequent widespread use [34], as seen in other countries [35].Increased detection of Shiga-toxin-producing E. coli (STEC) may not necessarily reflect increased disease, as the current case definition does not require that symptoms are present.For shigellosis, outbreaks disproportionately affecting Aboriginal and Torres Strait Islander people in northern and central Australia (2017-2019) [36] and men who have sex with men (MSM) in the eastern states (2017 onwards) [37] contributed to increased reporting rates.However, we observed a decrease in shigellosis notification incidence in 2020 and 2021 which may reflect that a proportion of these cases are imported.The observed increase in notification incidence of hepatitis A in 2018 was contributed to by two hepatitis A outbreaks: one associated with imported frozen pomegranate arils and one amongst MSM [38,39]; subsequent decreases in incidence likely reflect the implementation of vaccination programs for high-risk populations by most jurisdictions.Although 2020-2021 saw changes in eating habits due to restrictions on travel, social gatherings, and dining out, and increased time spent at home [40], the risk of foodborne infections remained, as evidenced by the high number of campylobacter notifications in 2020 and 2021.In contrast, largely imported gastrointestinal infections (e.g.typhoid) decreased in notification incidence in 2020-2021.
Overall, we observed a decrease in vector-borne disease notification incidence throughout the study, which was most marked for BFV.However, individual disease trends varied, likely reflecting both the source of acquisition (endemic vs. imported) and changing climactic conditions.The endemic vector-borne diseases BFV and Ross River virus (RRV) increased in notification incidence in 2020, with one explanation being increased rainfall resulting in increased mosquito vectors [41].Additionally, COVID-19-related closures of fitness and leisure facilities and restrictions on indoor gatherings may have led to more people engaging in local outdoor activities such as gardening, camping, and hiking, thereby increasing the risk of exposure [42].A similar trend was noted with tick-borne encephalitis (TBE) in Europe during 2020, with notifications increasing by 58% in Germany, thought to be partly due to increased engagement in outdoor activities [10].
Of particular note, notifications of Japanese encephalitis increased markedly in the first 6 months of 2022, reflecting the first outbreak of JE in south-eastern Australia, with the sentinel case for the outbreak occurring in 2021 [43].The geographical distribution of this outbreak is similar to that of previous outbreaks of other endemic flaviviruses (such as Murray Valley encephalitis virus) and is associated with La Niña weather conditions which have resulted in above average rainfall and extensive flooding, attracting waterbirds (reservoir hosts) and providing conditions for increased mosquito breeding [44].
Despite a marked increase in international travel in the years prior to the COVID-19 pandemic [45], including a record number of overseas trips by Australian travellers in 2019 [46], diseases that are primarily imported decreased by an average of 3% per year from 2012 to 2019.Unsurprisingly, we observed a decrease in imported diseases in 2020-2021 in the context of COVID-19 pandemic-related international travel disruptions.Similar to imported gastrointestinal diseases, the notification incidence of imported vector-borne diseases such as dengue, chikungunya, and malaria decreased substantially in 2020.This finding was similar to that seen in other high-and upper-middle-income countries [9][10][11].Although there were no notifications of measles in 2021, cases started to increase in 2022 (n= 7), and increased reports are expected in the context of the current global rise in cases and re-opened international borders as demonstrated by the latest Australian surveillance data showing 19 cases notified from 1 January to 11 September 2023 [47].
Other notable epidemiological findings include an ongoing reduction in notifications of invasive meningococcal disease secondary to serogroup C following the introduction of the vaccine to Australia's National Immunisation Program in 2003 [48].A subsequent rise in invasive meningococcal disease notifications since 2014 coincided with increases in serogroups W and Y [49], prompting states and territories to implement the meningococcal A, C, W, and Y (MenACWY) vaccination programs [49]; decreases in invasive meningococcal disease notification incidence then followed.Another notable finding was the steady decrease in ornithosis incidence from 2012 to 2019, with an increase in 2020 related to an outbreak in the Blue Mountains Local Government Area (LGA) in NSW and a significant increase in cases in the Alpine LGA in Victoria [50,51].Notification incidence of leptospirosis has increased by an average of 8% per year over the study period, with contributing factors including climactic conditions favouring outbreaks [52].
Our study has some limitations.Notifications represent the frequency of disease diagnosis but not necessarily incidence as notification fractions vary between diseases, jurisdictions, population subgroups, and over time.Notifications are also influenced by jurisdictional and local diagnostic, screening, case follow-up, and notification practices.Therefore, notification incidence alone cannot determine the population burden of infectious diseases.The case definitions of notifiable diseases undergo periodic revisions which will influence notification practices.Despite uniform case definitions, notification rates may be an underestimate of the number of infections especially if diseases cause mild or no symptoms.Other limitations to the analysis include the fact that diseases became notifiable at different time points since 1991, with some diseases becoming notifiable during the study period.Other diseases that were initially grouped together were separated into individual diseases which may influence notification rates.Although there is likely to be an association, we cannot demonstrate that the reported changes in incidence during the COVID-19 pandemic are causally associated with COVID-19 versus the extent to which competing priorities and increased pressure on public health personnel and laboratories explain the findings.Other factors that could affect the incidence of notifiable diseases were not assessed in detail, such as seasonal trends, effect of vaccination, and changes in the sensitivity of surveillance.

Conclusions
Notifiable disease notifications increased markedly during 2012-2022 compared to the previous 21 years.Prior to the COVID-19 pandemic, a steady increase in most notifiable diseases was observed, with the exception of bloodborne viral hepatitis, vector-borne diseases, and imported diseases.The pandemic had a variable impact on notification rates with substantial reductions in notifications of infectious diseases transmitted via the respiratory route such as influenza, invasive meningococcal disease and respiratory syncytial virus, and imported infections.This is likely, in part, due to non-pharmaceutical public health interventions implemented to prevent and control COVID-19.However, other diseases such as sexually transmissible infections remained stable, whereas some gastrointestinal diseases such as campylobacteriosis increased significantly.COVID-19-related public health measures likely resulted in a substantial number of averted notifications, particularly for sexually transmissible infections and gastrointestinal diseases.
editing of the manuscript.ACC also provided supervision.All authors read and approved the final manuscript.
• fast, convenient online submission • thorough peer review by experienced researchers in your field • rapid publication on acceptance • support for research data, including large and complex data types • gold Open Access which fosters wider collaboration and increased citations maximum visibility for your research: over 100M website views per year

•
At BMC, research is always in progress.

Learn more biomedcentral.com/submissions
Ready to submit your research Ready to submit your research ?Choose BMC and benefit from: ? Choose BMC and benefit from: N/A N/A N/A N/A N/A N/A N/A N/N/A N/A N/A N/A N/A N/A N/A N/A N/A 0

Table 1
Number, demographics, and crude incidence of case notifications by disease group and jurisdiction, Australia 2012-2022 NB overlap of individual diseases within the 'imported' disease group with other disease groups Age group missing data: 0.1% for all notifications with COVID-19 notifications accounting for 92% of missing data; 0.5% for Western Australia, 0.5% for Queensland; 0.3% for South Australia, Victoria Sex missing data: 5% for all notifications, 6% for respiratory diseases, 3% for the Australian Capital Territory.Queensland; 1% South Australia, Tasmania, Victoria; 37% for Western Australia with COVID-19 notifications accounting for > 99% of the missing data Notifications Sex Age group (years)

Table 2
Notification incidence (per 100,000 population per year) by year for disease groups and individual diseases, Australia 2012-2022

Table 2 (continued) Notifications Annual incidence Mean incidence over different time periods Change in annual incidence (2012-2019) 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 Mean
6.69-0.76;0.12 Incidence: 100,000 per population per year Average annual incidence change: percent per year Average annual change in incidence calculated for time period from 2012 to 2019 to provide a pre-COVID-19 pandemic trend; the average annual change in incidence for 'All diseases (includes COVID-19)' and 'all diseases (excludes COVID-19)' will be the same as COVID-19 only became notifiable in 2020 Diseases with zero notifications: Yellow fever, rabies, anthrax, Middle Eastern respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), poliomyelitis, viral haemorrhagic fever, lyssavirus unspecified, plague, smallpox, and avian influenza in humans Average annual change in incidence calculated for diseases with ≥ 400 notifications over the study period Imported diseases include cholera, typhoid, paratyphoid, hepatitis A, hepatitis E, Japanese encephalitis, malaria, dengue, chikungunya, measles, flavivirus (unspecified)